Not yet, but eventually

Die—but not just yet

eterochromatin’s repressive hold on DNA transcription can only be relinquished when activators enter the nucleus. Or so the theory goes. But now Vanessa Witte, Andreas Baur (University of Erlangen, Germany), and colleagues find that a heterochromatin component can be pulled from the nucleus by both the HIV protein Nef and activated integrins. “This is a really new concept—that chromatin-associa...

On third base but not home yet.

565 IN 28 YEARS of a busy and rewarding medical career I have had the opportunity to work in three different environments during three distinct stages of my career and life. As with many other young professionals I had some reasonable knowledge about how and when I would get to first base (medical degree and specialty). However, I was not able to predict when or where the next stage would take ...

Consistent Marks But Not Yet Ready for Promotion

In the present era that includes multiple potential treatment strategies for patients with acute and chronic coronary artery disease (CAD), a primary goal is to match the intensity of therapy with an individual patient’s risk for an adverse outcome. To accomplish this goal, improved risk stratification algorithms are needed. Among the potential strategies to improve risk assessment, measurement...

Closer but not there yet: models in child injury research.

Leads-to Properties and the But-not-yet Operator

We deene a predicate transformer, in terms of which nite disjunctions of leads-to properties can be rewritten as single leads-to properties. Although disjunctions of leads-to properties do not typically arise naturally in progress speciications, an example shows how they may be introduced through the use of nested implications of leads-to properties; such implications allow subtle dependencies ...